what is triamcinolone acetonide cream 0.1 used to treat poison ivy

Medicinal compound, steroid

Triamcinolone acetonide

Clinical data
Trade names	Kenalog, Volon A, Nasacort, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601124
License data	US  DailyMed:Triamcinolone
Pregnancy category	AU: B3(topical)
Routes of administration	Topical, articulation injection, suprachoroidal
ATC lawmaking	A01AC01 (WHO) D07AB09 (WHO), H02AB08 (WHO)
Legal status
Legal condition	AU: S4 (Prescription simply) / S3 / S2 Us: ℞-simply / OTC[1]
Pharmacokinetic data
Metabolism	Liver
Excretion	Urine (75%) and faeces (25%)
Identifiers
IUPAC proper name (4aS,4bR,5S,6aS,6bSouthward,9aR,10aS,10bDue south)-4b-fluoro-6b-glycoloyl-five-hydroxy-4a,6a,8,eight-tetramethyl-4a,4b,5,six,6a,6b,9a,x,10a,10b,11,12-dodecahydro-twoH-naphtho[2',1':4,v]indeno[1,two-d][i,3]dioxol-2-1
CAS Number	76-25-five Y
PubChem CID	6436
IUPHAR/BPS	2867
ChemSpider	6196 Y
UNII	F446C597KA
KEGG	D00983
ChEBI	CHEBI:71418 Northward
ChEMBL	ChEMBL1504 Y
CompTox Dashboard (EPA)	DTXSID6021371
ECHA InfoCard	100.000.863
Chemical and concrete data
Formula	C 24 H 31 F O 6
Tooth mass	434.504 chiliad·mol−i
3D model (JSmol)	Interactive image
Melting betoken	290 to 294 °C (554 to 561 °F)
SMILES C[C@]12C[C@@H]([C@]iii([C@H]([C@@H]1C[C@@H]iv[C@]two(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O
InChI InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-nine-14(27)seven-eight-21(13,3)23(15,25)17(28)xi-22(16,4)24(xix,31-xx)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 Y Fundamental:YNDXUCZADRHECN-JNQJZLCISA-N Y
N Y  (what is this?) (verify)

Triamcinolone acetonide is a synthetic corticosteroid medication used topically to treat various skin conditions,^[2] to relieve the discomfort of mouth sores, and intra-articularly by proceduralists to treat diverse joint conditions. It is besides injected intralesionally to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to care for allergic rhinitis. Information technology is a more potent derivative of triamcinolone, and is about viii times as potent as prednisone.^[3] It is used for the treatment of macular edema associated with uveitis.^[1]

It is also known nether the brand names Kenalog (topical) and Volon A equally an injection, to treat allergies, arthritis, eye diseases, intestinal problems, and skin diseases.

In 2014, the U.S. Food and Drug Assistants (FDA) made triamcinolone acetonide an over-the-counter drug in the United States in nasal spray form nether the brand name Nasacort.^[three]

Medical uses [edit]

Triamcinolone acetonide as an intra-articular injectable has been used to care for a variety of musculoskeletal conditions. When applied to the peel as a topical ointment, information technology is used to mitigate blistering from poison ivy, oak, and sumac.^{[ citation needed ]} When combined with nystatin, it is used to treat skin infections with discomfort from mucus, though it should non be used on the optics.^[four] It provides relatively immediate relief and is used before using oral prednisone. Oral and dental paste preparations are used for treating aphthous ulcers.

As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema.^[5] Drug trials take establish it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a two-year period. A systematic review did non find any show of whatever do good in preventing vision loss in eyes treated with triamcinolone acetonide over placebo, for patients with age-related macular degeneration.^[six]

Triamcinolone acetonide is also administered via intralesional injection in the handling of hypertrophic and keloid scars.^{[vii] [8]}

Uncommonly, intramuscular injection of triamcinolone acetonide may exist indicated for the command of severe or incapacitating allergic states for which conventional treatments accept failed, such as asthma, atopic dermatitis, contact dermatitis, perennial or seasonal allergic rhinitis, serum sickness, and transfusion and drug hypersensitivity reactions.

Contraindications [edit]

Evidence suggests that usage of triamcinolone acetonide or other steroids to treat macular edema increases the risk of increasing intraocular pressure in patients.^[ix]

Triamcinolone acetonide should not exist used past those with tuberculosis or untreated fungal, bacterial, systemic viral or herpes simplex infections without consulting a dr. first.

Pharmacology [edit]

Pharmacodynamics [edit]

Triamcinolone acetonide is a corticosteroid. It is specifically a glucocorticoid, or an agonist of the glucocorticoid receptor, that is nigh five times as potent as cortisol. It has very footling mineralocorticoid effects.^[10] The affinities of triamcinolone acetonide for the androgen and estrogen receptors are both <0.1% (relative to testosterone and estradiol).^[11] Nonetheless, triamcinolone acetonide has fifteen% of the affinity of progesterone for the progesterone receptor.^[11] In relation to this, triamcinolone acetonide tin produce endocrine side effects like ovulation inhibition and menstrual irregularities.^{[12] [xiii] [14]}

Chemistry [edit]

Triamcinolone acetonide, also known as 9α-fluoro-16α-hydroxyprednisolone 16α,17α-acetonide or every bit 9α-fluoro-11β,16α-17α,21-tetrahydroxypregna-ane,four-diene-3,20-dione cyclic 16,17-acetal with acetone, is a synthetic halogenated circadian ketal pregnane corticosteroid.^[fifteen] Information technology is the C16α,17α acetonide of triamcinolone.^[15]

Veterinary employ [edit]

Triamcinolone acetonide is also used in veterinary medicine as an ingredient in topical ointments and in topical sprays for control of pruritus in dogs.^[16] A serial of injections with triamcinolone acetonide or some other corticosteroid may reduce keloid size and irritation. It is used equally a preinductor and/or inductor of birth in cows. It was also used in the horse racing industry, simply information technology is at present a banned substance if constitute in a horse's system on race solar day.^[17]

See also [edit]

• Topical steroid

References [edit]

1. ^ ^{a b} "Xipere- triamcinolone acetonide injection, suspension". DailyMed . Retrieved nineteen December 2021.
2. ^ "Triamcinolone Topical". MedlinePlus . Retrieved 12 November 2020.
3. ^ ^{a b} "Nasacort Allergy 24HR- triamcinolone acetonide spray, metered". DailyMed. 3 Feb 2014. Retrieved 12 November 2020.
4. ^ "Nystatin And Triamcinolone (Topical Route)". mayoclinic.org. Mayo Foundation for Medical Educational activity and Research. Retrieved xviii May 2016.
5. ^ Rittiphairoj, Thanitsara; Mir, Tahreem A.; Li, Tianjing; Virgili, Gianni (17 November 2020). "Intravitreal steroids for macular edema in diabetes". The Cochrane Database of Systematic Reviews. 2020 (11): CD005656. doi:ten.1002/14651858.CD005656.pub3. ISSN 1469-493X. PMC8095060. PMID 33206392.
6. ^ Geltzer A, Turalba A, Vedula SS (2013). "Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular historic period-related macular degeneration". Cochrane Database Syst Rev (one): CD005022. doi:x.1002/14651858.CD005022.pub3. PMC4269233. PMID 23440797. {{cite periodical}}: CS1 maint: multiple names: authors list (link)
7. ^ "Intralesional Steroid Therapy (Patient Information Leaflets)". British Association of Dermatologists. 2008. Archived from the original on 15 March 2020. Retrieved 15 March 2020.
8. ^ Griffith, B.H. (1966). "The treatment of keloids with triamcinolone acetonide". Plastic and Reconstructive Surgery. 38 (3): 202–208. doi:10.1097/00006534-196609000-00004. PMID 5919603.
9. ^ Gewaily D, Muthuswamy K, Greenberg Lead (2015). "Intravitreal steroids versus observation for macular edema secondary to central retinal vein occlusion". Cochrane Database Syst Rev. 2021 (9): CD007324. doi:x.1002/14651858.CD007324.pub3. PMC4733851. PMID 26352007.
10. ^ Dinnendahl V, Fricke U, eds. (2004). Arzneistoff-Profile (in German). Vol. x (19 ed.). Eschborn, Frg: Govi Pharmazeutischer Verlag. Triamcinolon. ISBN978-three-7741-9846-3.
11. ^ ^{a b} Robert J. Kavlock; George P. Daston (6 December 2012). Drug Toxicity in Embryonic Development 2: Advances in Understanding Mechanisms of Nascency Defects: Mechanistics Understanding of Human Development Toxicants. Springer Science & Business organisation Media. pp. 437–. ISBN978-3-642-60447-8.
12. ^ Brook EM, Hu CH, Kingston KA, Matzkin EG (March 2017). "Corticosteroid Injections: A Review of Sexual activity-Related Side Effects". Orthopedics. 40 (two): e211–e215. doi:10.3928/01477447-20161116-07. PMID 27874912.
13. ^ Cunningham GR, Goldzieher JW, de la Pena A, Oliver Thousand (January 1978). "The mechanism of ovulation inhibition past triamcinolone acetonide". J Clin Endocrinol Metab. 46 (1): eight–14. doi:10.1210/jcem-46-ane-8. PMID 376542.
14. ^ Luzzani F, Gallico L, Glässer A (1982). "In vitro and ex vivo bounden to uterine progestin receptors of the rat as a tool to assay progestational activeness of glucocorticoids". Methods Notice Exp Clin Pharmacol. 4 (4): 237–42. PMID 7121132.
15. ^ ^{a b} J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Information: Chemic Information, Structures and Bibliographies. Springer. pp. 1228–. ISBN978-one-4757-2085-three.
16. ^ Genesis (triamcinolone acetonide) Topical Spray Drug information
17. ^ Champion Hurdle favourite Yanworth failed drug test

External links [edit]

• "Triamcinolone acetonide". Drug Information Portal. U.Due south. National Library of Medicine.
• "Triamcinolone". MedlinePlus.
• "Triamcinolone Nasal Spray". MedlinePlus.

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Source: https://en.wikipedia.org/wiki/Triamcinolone_acetonide

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